Research Areas
E-mail : chulee.y@chula.ac.th Phone : 662 218 5096
Chulee Yompakdee, Associate Professor, Ph.D.
Omics research of interest Proteomics analysis as a tool for understanding mechanism of action of bioactive compounds Natural products have been shown high promising resources for drug discovery. However, the majority of newly discovered natural products are only limited to biological activity with unknown targets. It is believed that natural products are more likely to have multiple targets. Therefore, it would be essential to study the mechanisms for the multiple component interactions. Our group is interested in using special engineered yeast strains for novel drug discovery from various natural resources such as medicinal plants and microbial metabolites. Shotgun proteomic approach will be used to study the biological process of cells in response to bioactive compounds. Then, the proteome data will be further analyzed by bioinformatics tools. Selected publications Suauam P, Yingyongnarongkul B, Palaga T, Miyakawa T, Yompakdee C. 2015. Clausmarin A, Potential Immunosuppressant Revealed by Yeast-Based Assay and Interleukin-2 Production Assay in Jurkat T Cells. PLOS One DOI: 10.1371/journal.pone.0136804 Personal URL http://www.micro.sc.chula.ac.th/index.php/en/about-us/67-staff/academic-staff/cerrent-academic-staff/4-yompakdee-chulee-assistant-professor-ph-d
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