Research Areas
 E-mail : tanapat.p@chula.ac.th Phone : 02 218 5095
Tanapat Palaga, Professor, Ph.D.
Omics research of interest Transcriptomics, Proteomics and Epigenetics in Innate Immune Cells and Cancer Cells

Our group is working on investigating the responses of macrophage, an innate immune cell, to various stimuli from pathogen-associated molecular patterns such as lipopolysaccharide and antigen-antibody immune complex. Understanding an overall macrophage response by transcriptomics and proteomics will provide novel ways to fine tune the immune response and modulate it to benefit the host. 
In addition, we also work on signal transduction leading to tumor development in hepatitis B virus (HBV)-mediated liver cancer. Our main focus in this area is how viral proteins regulate host gene expression in hepatocytes and tumor-associated macrophages leading to tumor development at transcriptional and epigenomic level. The overall goals is to understand transcriptomic and epigenetics changes conferred by HBV infection in liver cells. Selected publications 1. Kueanjinda, P, Roytrakul, S, Palaga, T*. A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4. (2015) Sci Rep. 5, 12784.

2. Wongchana W, Lawlor RG, Osborne BA, Palaga, T*. Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis. (2015) J Immunol. 195, 5337-5346.

3. Kongkavitoon P, Tangkijvanich P, Hirankarn N, Palaga, T*. Hepatitis B Virus HBx Activates Notch Signaling via Delta-like 4/Notch1 in Hepatocellular Carcinoma. (2016) PLoS One 11, e0146696. Personal URL http://www.micro.sc.chula.ac.th/index.php/en/about-us/67-staff/academic-staff/cerrent-academic-staff/14-tanapat-palaga-associate-professor-ph-d
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